Sometimes, extensive application of salicylic ointment to the skin (such as for wart removal) may cause salicylate poisoning. Salicylate poisoning may also occur with ingestion of oil of wintergreen (methyl salicylate). In young children, aspirin poisoning is usually accidental. The easy availability of the medicine is one of the reasons for aspirin being used for deliberate self-poisoning in adults. It can occur in adults as well as children. Salicylate poisoning is a potentially toxic level of salicylate in the blood which may be acute or chronic. Gastrointestinal bleeding is one of the more serious side effects of aspirin use.
Due to its antiplatelet effect, aspirin is prescribed in low doses for prevention of heart attack, stroke, and blood clot formation, and also after a heart attack to prevent future episodes of myocardial infarction. Despite this decline in reported deaths and general use, it is still imperative that clinicians are adept at early recognition and swift management of patients with salicylate overdose.Aspirin (acetylsalicylic acid) and other salicylates are present in many over-the-counter (OTC) drugs which are used as analgesics (pain relievers), antipyretics (for controlling fever), and anti-inflammatory medicines.
In the last 5 years of data available (2008–2012), there were 20 to 30 deaths per year reported ( Chap. The association with Reye syndrome safer packaging and the increased use of nonsteroidal antiinflammatory drugs (NSAIDs), APAP, and other alternatives to aspirin has decreased the incidence of unintentional salicylate poisoning. Salicylate toxicity and fatalities have long been a major toxicological “concern.” From the 1950s to 1970s, salicylate was the leading cause of fatal childhood poisoning.
Analgesics, which include both aspirin and acetaminophen (APAP), continue to rank first among pharmaceuticals most frequently reported in human exposures ( Chap. The American Association of Poison Control Centers (AAPCC) National Poison Data System (NPDS) collects and reports annual exposure data in the United States.
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